Isa Bey Mosque was built in 1374-1375 by Isa Bey of Aydınoğulları on Ayasuluk Hill by Architect Şamlı Dımışklıoğlu Ali. It is located between the Temple of Artemis and St.John's Basilica. The mosque, which exhibits the first examples of Anatolian mosque architecture, has rich ornaments and tiles. It was also used as a caravanserai in the 19th century. Ephesus Ancient City is located three kilometers southwest of Selçuk district of Izmir province. Ephesus Ancient City was established as a simple settlement in 8600 BC. It was transformed into a city by the Attic and Ionian Greek colonists in the 10th century BC. It was one of the twelve cities of Ionia in the classical Greek era. The city developed after it came under the control of the Roman Republic in 129 BC. During this period, Ephesus turned into one of the biggest metropolises of its age with a population of over 200,000. Ephesus Ancient City was added as a UNESCO World Heritage Site in 2015. According to the New Testament in the second part of the Bible, the Prophet Jesus appears to Saint (Apostle) John and gives "messages" to be delivered to the seven churches. Messages sent to these seven churches themselves, and are regarded as the first Christian churches in Turkey are located. M.S. Established by Saint (from Tarsus) Paul during the Roman Empire in 53-56, these churches are named after the Roman period: 1.Ephesus (Ephesos) (Selçuk) 2.İzmir (Smyrna) 3.Bergama (Pergamon) 4.Salihli ( Sardes) 5.Alaşehir (Philadelphia) 6.Denizli (Laodikeia) 7.Akhisar (Thyateira). Saint John (Saint John-Saint Jean) Church, one of the Seven Churches in Asia, is located in Ephesus. St.Paul (from Tarsus) tried very hard to spread Christianity in Ephesus and gave one of her famous sermons here.